Overview
In hospitalised adults with acute hypoxaemic respiratory failure not due to COVID-19 and who are deemed suitable for tracheal intubation, is an awake prone positioning strategy compared with standard care clinically- and cost-effective?
​Inclusion criteria​​​​
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Adult (age >18 years) hospitalised patient who is not intubated
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Acute hypoxaemic respiratory failure, defined as sustained SpO2 ≤ 94% whilst receiving ≥40% supplemental oxygen
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Deemed suitable for tracheal intubation in event of physiological deterioration
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​Exclusion criteria
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Hypoxaemia fully explained by acute pulmonary oedema due to heart failure
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Patient unwilling to attempt awake prone positioning
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Contraindication to awake prone positioning
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COVID-19 pneumonitis as primary cause of respiratory failure
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Invasive mechanical ventilation during current hospital admission (except where provided only to facilitate a procedure or operation)
